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Journal of the Korean Society for Aesthetic Plastic Surgery 2003;9(1):17-21.
Published online March 1, 2003.
The Evaluation of the Effect of Aminophylline Injection to Subcutaneous Fat Reduction.
Heung Kyu Kim, Yang Woo Kim, Han Jung Kim
Department of Plastic Surgery, College of Medicine, Ewha Womans University, Seoul, Korea. yangwkim@hotmail.com
Abstract
The obesity induce not only physical problem, but psychological and emotional problem. The focus of body contour procedures is the body's unequal distribution of fat. Aminophylline is a 2-adrenaline agonist, an adenosine inhibitor, and a phosphodiesterase inhibitor. It activates c-AMP, and facilitates lipolysis. Forty rats were used to study the effect of aminophylline subcutaneous injection, and divided in four groups, In the control group(n=10), saline was injected to subcutaneous fat of the abdomen. In the experimental group, aminophylline 50 mg/kg(n=10), 100 mg/kg(n=10) and 200 mg/kg(n=10) were injected. The injection was done daily for three weeks. The four groups were measured by weight, abdomen circumference, biochemistry, and histopathological test. There were no difference among the four groups. In conclusion, aminophylline subcutaneous injection is not effective in the reduction of regional and systemic fat.
Key Words: Aminophylline, Subcutaneous injection, Lipolysis
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